Universality of LNA-mediated high-affinity nucleic acid recognition
Universality of LNA-mediated high-affinity nucleic acid recognition
复制标题
DOI：
10.1039/a801571f
复制
发表时间：
1998-06-21
影响因子：
4.9
通讯作者：
Wengel, J
中科院分区：
文献类型：
--
作者：
Singh, SK;Wengel, J
LNA（锁核酸）是一类新型的核酸模拟物，结构上与RNA非常相似;三个LNA单体与六个核糖核苷酸单体的结合提供了第一个ribo-LNA序列; ribo-LNA获得了前所未有的双链体对互补DNA和RNA的热稳定性，而不影响碱基配对选择性，从而建立了LNA介导的天然核酸高效靶向的普遍性。
LNA (locked nucleic acid) is a novel class of nucleic acid mimic structurally closely resembling RNA; incorporation of three LNA monomers together with six ribonucleotide monomers afforded the first ribo-LNA sequence; unprecedented thermal stabilities of duplexes towards complementary DNA and RNA without compromising base-pairing selectivity were obtained for ribo-LNA, thus establishing the universality of LNA-mediated efficient targeting of natural nucleic acids.