TRANSFUSION-ASSOCIATED HEPATITIS NOT DUE TO VIRAL-HEPATITIS TYPE-A OR TYPE-B
TRANSFUSION-ASSOCIATED HEPATITIS NOT DUE TO VIRAL-HEPATITIS TYPE-A OR TYPE-B
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DOI：
10.1056/nejm197504102921502
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
HOLLAND, PV
中科院分区：
文献类型：
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作者：
FEINSTONE, SM;KAPIKIAN, AZ;HOLLAND, PV
22例输血相关性肝炎发作时B型肝炎抗原不阳性的患者进行了甲型和B型肝炎抗原、巨细胞病毒和EB病毒抗体检测。通过免疫电子显微镜测量对27 nm病毒样甲型肝炎抗原的抗体应答。在研究期间，22例患者中没有一例出现甲型肝炎病毒感染的血清学证据。22例患者中有9例对巨细胞病毒有抗体反应，但很难将这些血清转化与肝炎联系起来。此外，所有22名患者均已存在EB病毒抗体。至少有一部分抗原阴性输血相关性肝炎可能是由其他尚未确定的感染因子引起的。（《新英格兰医学杂志》292：767-770，1975）
Twenty-two patients who had an episode of transfusion-associated hepatitis not positive for hepatitis B antigen were examined for development of antibody to hepatitis A and B antigens, cytomegalovirus and Epstein-Barr virus. Antibody response to the 27-nm virus-like hepatitis A antigen was measured by immune electron microscopy. In none of the 22 patients studied did serologic evidence of infection with hepatitis A virus develop during the study period. Nine of the 22 patients had antibody responses to cytomegalovirus, but it was difficult to relate these seroconversions to their hepatitis. In addition, all 22 patients had pre-existing antibody to the Epstein-Barr virus. It seems likely that at least a proportion of such antigen-negative transfusion-associated hepatitis is caused by other infectious agents, not yet identified. (N Engl J Med 292:767–770, 1975)