Oral pathogenesis of Aggregatibacter actinomycetemcomitans
Oral pathogenesis of Aggregatibacter actinomycetemcomitans
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DOI：
10.1016/j.micpath.2017.11.001
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发表时间：
2017-12-01
影响因子：
3.8
通讯作者：
Kafil, Hossein Samadi
中科院分区：
文献类型：
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作者：
Gholizadeh, Pourya;Pormohammad, Ali;Kafil, Hossein Samadi
Aggregatibacteractinomycetemcomitans（A.放线菌属（actinomycetemcomitans）是一种革兰氏阴性的兼性厌氧杆菌，其引起牙周疾病，例如局部侵袭性牙周炎（localized aggressive periodontitis，PGEX）。因此。骨吸收该生物体的潜在毒力因子是强大的白细胞毒素、脂多糖（LPS）、细胞表面相关物质、酶和将调节宿主防御活性的不太明确的毒力因子。在牙周病中，这种微生物可以通过各种毒力因子诱导骨吸收。本文就A.放线菌在牙周病中的作用及其引起骨吸收的机制。一些研究结果表明，毒力因子和宿主免疫系统的反应之间的相互作用往往促进牙周病的骨吸收。在这种生物体中，GroEL、DnaK、HtpG、LTX、CDT、LPS和细胞表面相关物质在暴露于免疫系统时产生细胞因子。其产生的细胞因子是导致骨组织破坏和骨吸收的主要原因。伴放线菌性牙周炎
Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a Gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localized aggressive periodontitis (LAP) and. consequently. bone resorption. The potential virulence factors of this organism are powerful leukotoxin, lipopolysaccharide (LPS), cell surface-associated materials, enzymes, and less well-defined virulence factors that will modulate the activity of the host defenses. This organism can induce bone resorption by various virulence factors in periodontal disease. In this review article, we reviewed the pathogenic roles of A. actinomycetemcomttans in periodontal disease and the mechanism which can induce bone resorption. Findings from several studies indicate that the interaction between virulence factors and the host immune system's response often progress bone resorption in periodontal disease. In this organism, GroEL, DnaK, HtpG, LTX, CDT, LPS, and cell surface-associated materials produce cytokines when exposed to the immune system. The produced cytokines are the Main cause of tissue destruction and bone resorption in A. actinomycetemcomitans inflammation in periodontal disease.