An aberrant link between gamma oscillation and functional connectivity in A beta(1-42)-mediated memory deficits in rats
An aberrant link between gamma oscillation and functional connectivity in A beta(1-42)-mediated memory deficits in rats
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A beta（1-42）介导的大鼠记忆缺陷中伽玛振荡与功能连接之间的异常联系
DOI：
10.1016/j.bbr.2015.10.008
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发表时间：
2016
影响因子：
2.7
通讯作者：
Tian Xin
中科院分区：
文献类型：
--
作者：
Liu Tiaotiao;Bai Wenwen;Wang Ju;Tian Xin
阿尔茨海默病（Alzheimer's disease，AD）是一种逐渐导致老年人认知功能障碍的神经退行性疾病。工作记忆的损害通常在AD中观察到。由于淀粉样β肽（Aβ）是AD认知障碍的致病因子，因此，深入了解Aβ在AD认知障碍中的作用机制，有助于深入了解AD的病理生理机制。伽马振荡以及功能连接已经被认为在各种认知功能中发挥重要作用。伽马振荡被假设为神经网络协调相互作用的结果。然而，伽马振荡和工作记忆中的功能连接之间的时间联系仍然在很大程度上未被探索。此外，是否Aβ诱导的工作记忆缺陷是由于γ振荡和功能连接之间的异常联系？因此，本研究通过植入大鼠前额叶皮层（PFC）的多电极记录了对照组和Aβ注射组（Aβ组）在Y-迷宫工作记忆任务中的局部场电位（LFPs）。分别估计了LFP之间的γ振荡和功能连接。与对照组相比，Aβ组LFP之间的振荡和功能连接明显减弱。此外，伽玛振荡和功能连接之间的时间间隔进行了检查。注意到对照组中伽马振荡和功能连接之间的精确时间联系以及Aβ组中Aβ诱导的异常联系。我们的研究结果表明，γ振荡和功能连接之间的联系可能提供了一个潜在的机制，Aβ1-42诱导的工作记忆缺陷。
Alzheimer’s disease (AD) is a neurodegenerative disease that gradually induces cognitive deficits in the elderly. Impairment of working memory was typically observed in AD. As amyloid-β peptide (Aβ) is a causative factor for the cognitive impairments in AD, developing a mechanistic understanding of the contribution of Aβ to cognitive impairments may yield insights into the pathophysiology of AD. Gamma oscillations as well as functional connectivity have been recognized to play important roles in various cognitive functions. Gamma oscillation is hypothesized as the results of the coordinated interaction of neural network. However, the temporal link between gamma oscillation and functional connectivity in working memory has remained largely unexplored. Moreover, whether Aβ-induced working memory deficit is due to the abnormal link between gamma oscillation and functional connectivity? Therefore, in the present study, local field potentials (LFPs) were recorded via multi-electrodes implanted in rat prefrontal cortex (PFC) for the control group and Aβ-injected group (Aβ group) when they performed a Y-maze working memory task. Gamma oscillations and functional connectivity among LFPs were respectively estimated. Compared with the control group, the Aβ group showed significantly weaker oscillations and functional connectivity among LFPs. Moreover, the time gap between gamma oscillation and functional connectivity was examined. The precise temporal link between the gamma oscillation and functional connectivity in the control group and the Aβ-induced abnormal link in the Aβ group were noticed. Our results indicate that the link between gamma oscillation and functional connectivity may provide a potential mechanism for the Aβ1–42-induced working memory deficits.