Potassium tert-Butoxide-Promoted Acceptorless Dehydrogenation of N-Heterocycles
Potassium tert-Butoxide-Promoted Acceptorless Dehydrogenation of N-Heterocycles
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叔丁醇钾促进 N-杂环的无受体脱氢
DOI：
10.1002/adsc.201900499
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发表时间：
2019-07-16
影响因子：
5.4
通讯作者：
Yu, Zhengkun
中科院分区：
文献类型：
--
作者：
Liu, Tingting;Wu, Kaikai;Yu, Zhengkun
在无过渡金属存在的条件下，叔丁醇钾促进的氮杂环无受体脱氢反应可有效地生成氮杂芳烃和氢气。在KOtBu碱存在下，140 ℃邻二甲苯溶液中，六元和五元氮杂环化合物进行无受体脱氢反应，得到相应的氮杂芳烃和H2气体.本方案提供了一条方便的芳族含氮化合物和H-2气体的路线。
Potassium tert-butoxide-promoted acceptorless dehydrogenation of N-heterocycles was efficiently realized for the generation of N-heteroarenes and hydrogen gas under transition-metal-free conditions. In the presence of KOtBu base, a variety of six- and five-membered N-heterocyclic compounds efficiently underwent acceptorless dehydrogenation to afford the corresponding N-heteroarenes and H-2 gas in o-xylene at 140 degrees C. The present protocol provides a convenient route to aromatic nitrogen-containing compounds and H-2 gas.