Hyperthermic sensitization of mouse intestine to damage by X rays: the effect of sequence and temporal separation of the two treatments.
Hyperthermic sensitization of mouse intestine to damage by X rays: the effect of sequence and temporal separation of the two treatments.
复制标题
小鼠肠道对 X 射线损伤的热敏化：两种治疗的顺序和时间间隔的影响。
DOI：
10.1259/0007-1285-51-604-302
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
S. B. Field
中科院分区：
文献类型：
--
作者：
S. Hume;S. B. Field
在将成年小鼠的下半身浸入不同温度的水中之前或之后，用7至15戈伊的X射线照射其腹部。使用5天的存活率作为终点来估计X射线照射对肠的损伤的热增强。在50%存活水平下计算热增强率（定义为X射线剂量与X射线加热剂量之间的比率，以产生相同水平的损伤）。如果加热和照射仅间隔几分钟，则获得的值与其他正常组织报告的值相似。只有轻微的依赖性的顺序的两个治疗。随着两次处理之间的时间间隔增加，热的影响降低，并且当间隔大于约4小时时获得正常的辐照响应。与其他正常组织和肿瘤的结果进行了比较，并讨论了这些研究结果在设计最佳治疗方案的组合热和X射线的相关性。
Adult mice were irradiated with between 7 and 15 Gy of X rays to the abdomen either before or after immersion of the lower half of the body in water at various temperatures. The thermal enhancement of X-irradiation damage to the intestine was estimated using survival at five days as the endpoint. Thermal enhancement ratios (defined as the ratio between the dose of X rays and the dose of X rays plus heat to produce the same level of damage) were calculated at the 50% survival level. If only a few minutes separated the application of heat and irradiation, the values obtained were similar to those reported for other normal tissues. There was only a slight dependence on the sequence of the two treatments. As the time interval between the two treatments was increased the effect of heat was reduced and a normal irradiation response was obtained when the separation was greater than about four hours. The results are compared with those for other normal tissues and tumours and the relevance of these findings in the design of optimal therapeutic schedules of combined heat and X rays is discussed.