Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia
Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia
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DOI：
10.1080/j.1440-1614.2006.01777.x
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发表时间：
2006-03-01
影响因子：
4.6
通讯作者：
Scarr, E
中科院分区：
文献类型：
--
作者：
Dean, B;Gray, L;Scarr, E
目的：确定在精神分裂症或双相I型障碍患者的大脑皮层中，神经胶质源性蛋白S100β和胶质纤维酸性蛋白（GFAP）以及促凋亡蛋白和抗凋亡蛋白p53和Bcl - 2的水平是否发生改变。
方法：使用蛋白特异性抗体和蛋白质印迹分析，测量对照组受试者以及精神分裂症、双相I型障碍患者大脑皮层（布罗德曼区域（BAs）9、10、46和40）中S100β、GFAP、p53和Bcl - 2的水平，同时测量用氟哌啶醇或锂处理的大鼠大脑皮层中的这些蛋白水平。
结果：双相I型障碍患者的布罗德曼区域9中S100β水平降低，在区域40中升高。在中枢神经系统的其他区域、精神分裂症患者中或者用氟哌啶醇或锂处理的大鼠大脑皮层中，该蛋白水平没有改变。在不同诊断中，未检测到其他三种蛋白水平的变化。
结论：大脑皮层S100β的区域选择性变化可能与双相I型障碍的病理相关，并且可能反映神经元死亡或存活的紊乱。
Objective: To determine if levels of the glial-derived proteins S100 beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder.Method: Levels of S100 beta, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis.Results: Levels of S100 beta were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses.Conclusions: Regionally selective changes in cortical S100 beta may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival.