Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action.
Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action.
复制标题
睡茄根提取物对氟哌啶醇引起的口面运动障碍的影响：可能的作用机制。
DOI：
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发表时间：
2003
影响因子：
2.4
通讯作者：
S. Kulkarni
中科院分区：
文献类型：
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作者：
P. Naidu;Amanpreet Singh;S. Kulkarni
我们研究了氧化应激在氟哌啶醇（HP）诱导的口面运动障碍的病理生理学中的作用，并评估了睡茄根提取物在改善TD大鼠模型中HP诱导的空咀嚼运动（VCM）和舌突起方面的有益作用。大鼠腹腔注射HP（1 mg/kg）治疗21天;第22天，在5分钟观察期内对VCM和舌突起进行计数。HP处理的大鼠显着开发这些锥体外系症状，但共同管理的WS根提取物（100-300毫克/公斤）剂量依赖性地减少他们。生化分析表明，慢性HP治疗显着增加脂质过氧化反应，降低前脑谷胱甘肽和抗氧化防御酶，超氧化物歧化酶（SOD）和过氧化氢酶的水平。Ws提取物的共同管理显着降低脂质过氧化反应，并显着逆转前脑SOD和过氧化氢酶水平的下降，但对HP诱导的前脑谷胱甘肽水平下降没有显着影响。这些研究结果强烈表明，氧化应激在HP诱导的口面运动障碍中起着重要作用，并且WS可以有效地预防抗精神病药诱导的锥体外系副作用。
We investigated the role of oxidative stress in the pathophysiology of haloperidol (HP)-induced orofacial dyskinesia and evaluated the beneficial effect of Withania somnifera (Ws) root extract in the amelioration of HP-induced vacuous chewing movements (VCMs) and tongue protrusions in the rat model for TD. Rats were treated for 21 days with intraperitoneal HP (1 mg/kg); on day 22, VCMs and tongue protrusions were counted during a 5-minute observation period. HP-treated rats significantly developed these extrapyramidal symptoms, but coadministration of Ws root extract (100-300 mg/kg) dose-dependently reduced them. Biochemical analysis revealed that chronic HP treatment significantly increased lipid peroxidation and decreased forebrain levels of glutathione and the antioxidant defense enzymes, superoxide dismutase (SOD) and catalase. Coadministration of Ws extract significantly reduced the lipid peroxidation and significantly reversed the decrease in forebrain SOD and catalase levels but had no significant effect on the HP-induced decrease in forebrain glutathione levels. These findings strongly suggest that oxidative stress plays a significant role in HP-induced orofacial dyskinesia and that Ws could be effective in preventing neuroleptic-induced extrapyramidal side effects.
DOI：
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发表时间：
2000-04
期刊：
The Journal of clinical psychiatry
影响因子：
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作者：
D. Casey
通讯作者：
D. Casey