A NEW HOMEO-BOX IS PRESENT IN OVERLAPPING COSMID CLONES WHICH DEFINE THE MOUSE HOX-1 LOCUS
A NEW HOMEO-BOX IS PRESENT IN OVERLAPPING COSMID CLONES WHICH DEFINE THE MOUSE HOX-1 LOCUS
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DOI：
10.1002/j.1460-2075.1986.tb04452.x
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发表时间：
1986-08-01
期刊：
影响因子：
11.4
通讯作者：
GALLIOT, B
中科院分区：
文献类型：
--
作者：
DUBOULE, D;BARON, A;GALLIOT, B
一个新的小鼠同源盒(Hox1-3)已被分离出来，并对其结构和转录模式进行了研究。这个同源盒是一个基因的一部分，该基因在小鼠出生前的发育过程中受到特定的调控，并在数量有限的畸胎癌肿瘤和成人睾丸中表达。Hox1-3被证明是位于小鼠6号染色体上一段75kb DNA片段内的至少四个同源框组成的簇的成员。给出了整个簇的结构，Hox-1基因座。
A new murine homeo-box (Hox1-3) has been isolated and studied with respect to its structure and transcriptional pattern. This homeo-box is part of a gene which is specifically regulated during mouse prenatal development and expressed in a restricted number of teratocarcinoma tumours as well as in adult testis. Hox1-3 is shown to be a member of a cluster of at least four homeo-boxes lying within a 75-kb segment of DNA on mouse chromosome 6. The structure of the whole cluster, the Hox-1 locus is presented.