Sex Differences in the Biomechanics and Contractility of Intramural Coronary Arteries in Angiotensin II-Induced Hypertension
Sex Differences in the Biomechanics and Contractility of Intramural Coronary Arteries in Angiotensin II-Induced Hypertension
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DOI：
10.1016/j.genm.2012.10.012
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发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Varbiro, Szabolcs
中科院分区：
文献类型：
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作者：
Matrai, Mate;Hetthessy, Judit;Varbiro, Szabolcs
背景：众所周知，在高血压的发病机制和治疗上都存在性别差异。目的：在实验动物实验中，我们研究了在心脏血液供应中起重要作用的壁内小冠状动脉血管适应的早期机制。方法：在本研究中，我们将渗透性微泵植入雄性和雌性SD大鼠各10只。泵在原地停留4周，注入100 ng/kg/min的血管紧张素II醋酸酯。四周后，动物被宰杀，来自左冠状动脉分支的壁内冠状动脉准备就绪，这些动脉从根本上负责心脏的血液供应。结果：女性心脏相对质量和血管壁厚度均大于男性(0.387[0.009]g/100g比0.306[0.006]g/100g体重；50 mm Hg41.9[4.09]µm比33.45[3.37]µm)。然而，对血栓素激动剂反应的血管张力和血管收缩在男性中明显更明显。女性对缓激肽反应的松弛程度也更大。虽然我们在女性中观察到了向内的富营养性重塑，但男性的血管壁应力和弹性模数的增加占主导地位。结论：血管紧张素II依赖型高血压的早期阶段在男性和女性中引发了非常不同的适应机制。(Gend Med.2012；9：548-556)Crown版权所有(C)2012由Elsevier HS Journal，Inc.出版。保留所有权利。
Background: It is well known that sex differences occur in both the pathogenesis and therapy of hypertension. A deeper understanding of the underlying processes may be helpful when planning a personalized therapeutic strategy.Objective: In laboratory animal experiments, we studied the early mechanisms of vascular adaptation of the intramural small coronary arteries that play a fundamental role in the blood supply of the heart.Methods: In our study, an osmotic minipump was implanted into 10 male and 10 female Sprague-Dawley rats. The pump remained in situ for 4 weeks, infusing a dose of 100 ng/kg/min angiotensin II acetate. Four weeks later, the animals were killed, and the intramural coronary arteries from the left coronary branch, which are fundamentally responsible for the blood supply of the heart, were prepared. The pharmacologic reactivity and biomechanical properties of the prepared segments were studied in a tissue bath.Results: The relative heart mass and vessel wall thickness were greater in females than males (0.387 [0.009] g/100 g vs 0.306 [0.006] g/100 g body weight; 41.9 [4.09] mu m vs 33.45 [3.37] mu m on 50 mm Hg). The vessel tone and vasoconstriction in response to thromboxane agonists were, however, significantly more pronounced in males. The extent of relaxation in response to bradykinin was also greater in females. Although we observed inward eutrophic remodeling in females, an increase in wall stress and elastic modulus dominated in males.Conclusion: The early steps of angiotensin II-dependent hypertension evoked very different adaptation mechanisms in males and females. (Gend Med. 2012;9:548-556) Crown Copyright (c) 2012 Published by Elsevier HS Journals, Inc. All rights reserved.