Emerging Insights into Antibiotic-Associated Diarrhea and Clostridium difficile Infection through the Lens of Microbial Ecology.
Emerging Insights into Antibiotic-Associated Diarrhea and Clostridium difficile Infection through the Lens of Microbial Ecology.
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DOI：
10.1155/2008/125081
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发表时间：
2008
影响因子：
--
通讯作者：
Young VB
中科院分区：
文献类型：
--
作者：
Walk ST;Young VB
抗生素是预防和积极治疗人类细菌感染的主要且通常唯一的临床干预措施。也许这并不奇怪，这些药物也改变了我们体内肠道细菌的组成，特别是肠道微生物群落（微生物群）中的细菌。然而，这些动力学最终如何影响肠道微生物群的功能还没有得到充分的认识。同样，抗生素诱导的变化如何促进某些细菌菌株的生长和致病性仍然是个谜。在这里，我们讨论了微生物生态学方法的优点，以了解抗生素使用的常见副作用，抗生素相关性腹泻（AAD），和机会性细菌感染，有时underlyingit.As一个例子，我们讨论了这种方法是如何被用来解决复杂的疾病动力学在艰难梭菌感染。
Antibiotics are the main, and often only, clinical intervention for prophylactic and active treatment of bacterial infections in humans. Perhaps it is not surprising that these drugs also shift the composition of commensal bacteria inside our bodies, especially those within the gut microbial community (microbiota). How these dynamics ultimately affect the function of the gut microbiota, however, is not fully appreciated. Likewise, how antibiotic induced changes facilitate the outgrowth and pathogenicity of certain bacterial strains remains largely enigmatic. Here, we discuss the merits of a microbial ecology approach toward understanding a common side effect of antibiotic use, antibiotic-associated diarrhea (AAD), and the opportunistic bacterial infections that sometimes underlie it. As an example, we discuss how this approach is being used to address complex disease dynamics during Clostridium difficile infection.