Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex
Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex
复制标题
DOI：
10.1126/science.1143808
复制
发表时间：
2008-01-04
期刊：
影响因子：
56.9
通讯作者：
Barth, Alison L.
中科院分区：
文献类型：
--
作者：
Clem, Roger L.;Celikel, Tansu;Barth, Alison L.
体内经验可以阻断随后的长时程增强诱导，增强突触反应的长时程抑制.虽然突触强化能力的降低可能起到防止过度兴奋的作用，但这种效果自相矛盾地意味着持续的经验或训练不应该改善，甚至可能会降低神经表征。在小鼠中，我们研究了持续的胡须刺激对桶皮质中第4-2/3层突触的突触强化的影响。虽然N-甲基- D-天冬氨酸受体需要启动加强，他们随后抑制进一步增强这些突触在体外和体内。尽管有这种过渡，突触强化继续与额外的感觉活动，而是需要代谢型谷氨酸受体的激活，这表明一种机制，通过这种机制，持续的经验可以导致随着时间的推移增加突触强度。
In vivo experience can occlude subsequent induction of long- term potentiation and enhance long- term depression of synaptic responses. Although a reduced capacity for synaptic strengthening may function to prevent excessive excitation, such an effect paradoxically implies that continued experience or training should not improve and may even degrade neural representations. In mice, we examined the effect of ongoing whisker stimulation on synaptic strengthening at layer 4-2/3 synapses in the barrel cortex. Although N- methyl- D- aspartate receptors were required to initiate strengthening, they subsequently suppressed further potentiation at these synapses in vitro and in vivo. Despite this transition, synaptic strengthening continued with additional sensory activity but instead required the activation of metabotropic glutamate receptors, suggesting a mechanism by which continued experience can result in increasing synaptic strength over time.