Depression, Antidepressant Use and Mortality in Later Life: The Health in Men Study
Depression, Antidepressant Use and Mortality in Later Life: The Health in Men Study
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DOI：
10.1371/journal.pone.0011266
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发表时间：
2010-06-23
期刊：
影响因子：
3.7
通讯作者：
Flicker, Leon
中科院分区：
文献类型：
--
作者：
Almeida, Osvaldo P.;Alfonso, Helman;Flicker, Leon
内容：抑郁症与死亡率增加有关，但尚不清楚这种关系是否具有剂量依赖性，以及是否可以通过抗抑郁药治疗来改变。目的：为了确定（1）抑郁症和死亡率之间的关联是否独立于晚年其他常见的潜在死亡原因，（2）抑郁症严重程度的增加和死亡率之间是否存在剂量反应关系，方法：对居住在澳大利亚珀斯的5,276名年龄在68-88岁之间的社区男性进行队列研究。我们使用老年抑郁量表15项（GDS-15），以确定抑郁症的存在和严重程度。GDS-15 >= 7表明存在临床显著抑郁症。男性也根据症状的严重程度进行分组：“无症状”（GDS-15=0），“可疑”（1
Context: Depression is associated with increased mortality, but it is unclear if this relationship is dose-dependent and if it can be modified by treatment with antidepressants.Objective: To determine if (1) the association between depression and mortality is independent of other common potential causes of death in later life, (2) there is a dose-response relationship between increasing severity of depression and mortality rates, and (3) the use of antidepressant drugs reduces mortality rates.Methods: Cohort study of 5,276 community-dwelling men aged 68-88 years living in Perth, Australia. We used the Geriatric Depression Scale 15-items (GDS-15) to ascertain the presence and severity of depression. GDS-15 >= 7 indicates the presence of clinically significant depression. Men were also grouped according to the severity of symptoms: "no symptoms'' (GDS-15=0), "questionable'' (1