A facile synthesis of cajaninstilbene acid and its derivatives
A facile synthesis of cajaninstilbene acid and its derivatives
复制标题
木豆苷二苯乙烯酸及其衍生物的简便合成
DOI：
10.1016/j.cclet.2019.04.043
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发表时间：
2019-08-01
影响因子：
9.1
通讯作者：
Chen，Wei-Min
中科院分区：
文献类型：
--
作者：
Chen，Qi;Lu，Kuo;Chen，Wei-Min
报道了 6-甲酰基-2-羟基-4-甲氧基-3-(3-甲基丁-2-en-1-基)苯甲酸甲酯 (11) 的四步合成，该合成可用作木豆茋二烯酸及其衍生物的简易合成的基础结构单元。以商业原料为原料，通过TiCl4介导的[3 + 3]环化和McMurry偶联合成，共分6步合成，总收率为20%。
A four-step synthesis of methyl 6-formyl-2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)benzoate (11) that can be used as building block for a facile synthesis of cajaninstilbene acid and its derivatives is reported. The synthesis of cajaninstilbene acid was accomplished in six steps with an overall yield of 20% starting from commercial materials by a synthesis whose key steps are TiCl4-mediated [3 + 3] cyclization and McMurry coupling.