Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes.
Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes.
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DOI：
10.1084/jem.162.5.1421
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发表时间：
1985-11-01
期刊：
影响因子：
--
通讯作者：
Weissman IL
中科院分区：
文献类型：
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作者：
Tidmarsh GF;Dailey MO;Whitlock CA;Pillemer E;Weissman IL
注射Abelson鼠白血病病毒（A-MuLV）的动物迅速发展为致命的骨髓源性淋巴肉瘤。在所有检测的这些患病动物中，骨髓细胞亚群表达单克隆抗体定义的B谱系转化相关抗原（6C 3 Ag），其水平高于正常淋巴细胞上检测到的水平。通过在琼脂中的克隆生长测量，发现具有高水平该抗原的细胞被转化，并且它们表达早期前B细胞的特征性表面抗原标志物。在患病动物的骨髓、淋巴结和脾脏中发现高水平的抗原表达细胞，但在胸腺中从未发现。该分布与已发表的Abelson病病理学一致。
Animals injected with Abelson murine leukemia virus (A-MuLV) rapidly develop fatal bone marrow-derived lymphosarcomas. In all such diseased animals tested, a subpopulation of bone marrow cells expressed a monoclonal antibody-defined, B lineage transformation-associated antigen (6C3 Ag) at levels increased from that detected on normal lymphocytes. Cells bearing a high level of this antigen were found to be transformed as measured by clonal growth in agar, and they expressed surface antigen markers characteristic of early pre-B cells. High-level antigen-expressing cells were found in the bone marrow, lymph nodes, and spleen, but never in the thymus of diseased animals. This distribution agrees with the published pathology of Abelson disease.