Excess pressure as an analogue of blood flow velocity
Excess pressure as an analogue of blood flow velocity
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DOI：
10.1097/hjh.0000000000002662
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发表时间：
2021-03-01
影响因子：
4.9
通讯作者：
Sharman, James E.
中科院分区：
文献类型：
--
作者：
Armstrong, Matthew K.;Schultz, Martin G.;Sharman, James E.
从血压波形推导血流速度是一种新技术，可能具有潜在的临床重要性。通过水库-超压模型从血压波形中计算出的超压，据称是血液流速的模拟，但这从未被详细研究过，而这正是本研究的目的。方法：通过充液导管依次测量肱动脉和桡动脉内血压，同时通过对侧手臂多普勒超声记录血流速度波形（n = 98，年龄61±10岁，72%男性）。使用仅压力库-超压分析，从动脉内血压波形中获得超压。结果：肱动脉和桡动脉血流速度波形形态与各自测量部位的超压非常接近（肱动脉和桡动脉的中位相关系数分别为r = 0.96和r = 0.95）。在频率分析中，肱动脉和桡动脉血流速度和超压之间的一致性相似（肱动脉和桡动脉中位一致性分别为0.93和0.92）。肱动脉和桡动脉血流速度脉冲高度与各自的超压脉冲高度相关（r = 0.53, P r = 0.43, P < 0.001）。结论：超压是血液流速的类似物，因此仅使用血压波形就可以获得与动脉血流相关的潜在重要信息。
Introduction: Derivation of blood flow velocity from a blood pressure waveform is a novel technique, which could have potential clinical importance. Excess pressure, calculated from the blood pressure waveform via the reservoir-excess pressure model, is purported to be an analogue of blood flow velocity but this has never been examined in detail, which was the aim of this study. Methods: Intra-arterial blood pressure was measured sequentially at the brachial and radial arteries via fluid-filled catheter simultaneously with blood flow velocity waveforms recorded via Doppler ultrasound on the contralateral arm (n = 98, aged 61 +/- 10 years, 72% men). Excess pressure was derived from intra-arterial blood pressure waveforms using pressure-only reservoir-excess pressure analysis. Results: Brachial and radial blood flow velocity waveform morphology were closely approximated by excess pressure derived from their respective sites of measurement (median cross-correlation coefficient r = 0.96 and r = 0.95 for brachial and radial comparisons, respectively). In frequency analyses, coherence between blood flow velocity and excess pressure was similar for brachial and radial artery comparisons (brachial and radial median coherence = 0.93 and 0.92, respectively). Brachial and radial blood flow velocity pulse heights were correlated with their respective excess pressure pulse heights (r = 0.53, P r = 0.43, P < 0.001, respectively). Conclusion: Excess pressure is an analogue of blood flow velocity, thus affording the opportunity to derive potentially important information related to arterial blood flow using only the blood pressure waveform.