Elevated human epididymis protein 4 concentrations in chronic kidney disease
Elevated human epididymis protein 4 concentrations in chronic kidney disease
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DOI：
10.1258/acb.2011.011258
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发表时间：
2012-07-01
影响因子：
2.2
通讯作者：
Kappelmayer, Janos
中科院分区：
文献类型：
--
作者：
Nagy, Bela, Jr.;Krasznai, Zoard T.;Kappelmayer, Janos
背景：人附睾蛋白4 （HE4）最近与标准癌抗原125 （CA125）一起成为检测卵巢癌的一种可用的肿瘤生物标志物。然而，目前尚不清楚HE4和CA125水平是否会在肾功能受损但无卵巢疾病的受试者中发生改变。方法：采用化学发光微粒子免疫分析法（Architect (R)，雅培公司）和电化学发光免疫分析法（Modular E170 (R)，罗氏公司）分别对113例无卵巢癌、肺癌的女性慢性肾脏病（CKD）患者和68例肾功能、卵巢功能正常的患者进行HE4和CA125浓度分析。通过测定血清肌酐和尿素浓度评估肾功能（Cobas Integra-800 (R)，罗氏）。估算肾小球滤过率（eGFR（单位：mL/min/1.73 m(2)））采用4v-MDRD公式计算。结果：不同eGFR值降低的个体HE4浓度显著升高（P < 0.0001） (
Background: Human epididymis protein 4 (HE4) has recently become an available tumour biomarker for detecting ovarian cancer along with the standard cancer antigen 125 (CA125). However, it is unknown if the levels of HE4 and CA125 may be altered in subjects who have impaired renal function with no ovarian disorders.Methods: In 113 female patients at different stages of chronic kidney disease (CKD) with no ovarian and lung cancer and 68 subjects with normal renal and ovarian function, HE4 and CA125 concentrations were analysed by using chemiluminescent microparticle immunoassay (Architect (R), Abbott) and electrochemiluminescent immunoassay (Modular E170 (R), Roche), respectively. Renal function was evaluated by measuring serum creatinine and urea concentrations (Cobas Integra-800 (R), Roche). Estimated glomerular filtration rate (eGFR in mL/min/1.73 m(2)) was calculated by the 4v-MDRD formula.Results: Significantly increased HE4 concentrations (P < 0.0001) were found in individuals with differently decreased eGFR values (