Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
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DOI：
10.1038/nrm3999
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Steller H
中科院分区：
文献类型：
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作者：
Fuchs Y;Steller H
所有的生命都以死亡告终，但也许生命中最大的讽刺之一是，它也依赖于死亡。细胞内源性自杀途径，称为程序性细胞死亡（PCD），是动物发育、组织稳态和发病机制的关键。最初，PCD实际上是细胞凋亡的同义词，但最近，已经报道了替代的PCD机制。在这里，我们提供了几个不同的PCD机制，即细胞凋亡，自噬和坏死性凋亡的概述。此外，我们还讨论了垂死细胞发出的复杂信号，这些信号既可以促进再生，也可以指示额外的杀伤。进一步了解多个细胞死亡机制和相关信号的生理作用的进展将是重要的选择性地操纵PCD用于治疗目的。
All life ends in death, but perhaps one of life’s grander ironies is that it also depends on death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for animal development, tissue homeostasis and pathogenesis. Originally, PCD was virtually synonymous with apoptosis, but recently, alternative PCD mechanisms have been reported. Here, we provide an overview of several distinct PCD mechanisms, namely apoptosis, autophagy and necroptosis. In addition, we discuss the complex signals emanating from dying cells, which can either fuel regeneration or instruct additional killing. Further advances in understanding the physiological role of multiple cell death mechanisms and associated signals will be important to selectively manipulate PCD for therapeutic purposes.