Submicrometer axial resolution optical coherence tomography
Submicrometer axial resolution optical coherence tomography
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DOI：
10.1364/ol.27.001800
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发表时间：
2002-10-15
期刊：
影响因子：
3.6
通讯作者：
Scherzer, E
中科院分区：
文献类型：
--
作者：
Povazay, B;Bizheva, K;Scherzer, E
光学相干断层扫描（OCT）与前所未有的亚微米轴向分辨率实现了使用光子晶体光纤与紧凑的子10-fs钛：蓝宝石激光器（飞秒激光器产品）的组合证明了作者认为是第一次。发射光谱范围从550到950 nm（λ（c）= 725 nm，P-out = 27 mW），导致自由空间轴向OCT分辨率近似于0.75 μ m，对应于生物组织中的近似于0.5 μ m。亚微米分辨率OCT在体外对人结肠直肠腺癌细胞HT-29进行了验证。这种新型光源的光谱覆盖了多种生物生色团的吸收带，具有很大的光谱OCT发展潜力。(C)2002年美国光学学会。
Optical coherence tomography (OCT) with unprecedented submicrometer axial resolution achieved by use of a photonic crystal fiber in combination with a compact sub-10-fs Ti:sapphire laser (Femtolasers Produktions) is demonstrated for what the authors believe is the first time. The emission spectrum ranges from 550 to 950 nm (lambda(c) = 725 nm, P-out = 27 mW), resulting in a free-space axial OCT resolution of similar to0.75 mum, corresponding to similar to0.5 mum in biological tissue. Submicrometer-resolution OCT is demonstrated in vitro on human colorectal adenocarcinoma cells HT-29. This novel light source has great potential for development of spectroscopic OCT because its spectrum covers the absorption bands of several biological chromophores. (C) 2002 Optical Society of America.