Disruption of reflexive attention and eye movements in an individual with a collicular lesion.
Disruption of reflexive attention and eye movements in an individual with a collicular lesion.
复制标题
脑丘病变患者的反射性注意力和眼球运动受到干扰。
DOI：
10.1080/13803390590929298
复制
发表时间：
2006
影响因子：
2.2
通讯作者：
Szapiel,SusanV
中科院分区：
文献类型：
--
作者：
Sereno,AnneB;Briand,KevinA;Amador,SilviaC;Szapiel,SusanV
上级丘（SC）在扫视眼球运动的控制中起着核心作用，并且还与内隐空间注意的控制有关。虽然有越来越多的证据来自对清醒行为的灵长类动物的研究，支持这些建议，但来自人类的直接证据很少。在本研究中，我们测试了一名患者硫胺素缺乏症和病变的SC，谁进行眼动任务（前视和反视，有或没有差距）和一个隐蔽的空间注意任务评估抑制返回（IOR）。对于眼球运动，差距效应被破坏，并且发生异常扫视度量，其中反射性眼球运动比自主性眼球运动被破坏得更多。这些影响中的每一个都与硫胺素治疗同时解决。内隐注意任务显示完全没有返回抑制。自愿和反射性眼球运动的不平等中断支持了这样一种观点，即眼动反应可以由额叶皮层和较低级别的神经系统以独立的方式产生。SC和其他结构在这些定向过程中的作用进行了讨论。
The superior colliculus (SC) plays a central role in the control of saccadic eye movements and has also been implicated in control of covert spatial attention. While there is a growing body of evidence from studies of awake behaving primates that supports these proposals, direct evidence from humans has been sparse. In the present study we tested a patient with thiamine deficiency and a lesion of the SC, who performed both eye movement tasks (prosaccades and antisaccades, with or without a gap) and a covert spatial attention task assessing inhibition of return (IOR). For eye movements, the gap effect was disrupted, and abnormal saccade metrics occurred, with reflexive eye movements being disrupted moreso than voluntary eye movements. Each of these effects resolved coincident with thiamine treatment. The covert attention task revealed a complete absence of IOR. The unequal disruption of voluntary and reflexive eye movements supports the idea that oculomotor responses can be generated in an independent fashion by frontal cortical and lower level neural systems. The role of the SC and other structures in these orienting processes is discussed.