Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort)
Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort)
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DOI：
10.3390/nu7125521
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发表时间：
2015-12-01
期刊：
影响因子：
5.9
通讯作者：
Sandberg, Ann-Sofie
中科院分区：
文献类型：
--
作者：
Barman, Malin;Nilsson, Staffan;Sandberg, Ann-Sofie
暴露于多不饱和脂肪酸（PUFA）会影响免疫功能，并可能影响过敏发展的风险。长链PUFA是由FADS和FADVL基因编码的去饱和酶和延伸酶催化的膳食前体产生的。在211名受试者中，我们调查了FADS基因簇和HPVL 2基因的多态性是否与瑞典出生队列中出生时和13岁时采样的血清磷脂中的过敏或PUFA成分相关;过敏在13岁时被诊断出来。在13岁时，rs 102275和rs 174448（FADS基因簇）的次要等位基因携带者脐带血和青少年血清中20：4 n-6的比例降低，脐带血中20：3 n-6的比例增加，并且发生特应性湿疹的风险名义上降低，但不发生呼吸道过敏。RsVL 2基因中rs 17606561的次要等位基因携带者在脐带血清中的20：4 n-6比例名义上降低，但RsVL多态性（rs 2236212和rs 17606561）与过敏发展无关。因此，由于FADS多态性导致的n-6 PUFAs去饱和能力降低与湿疹发生风险降低相关，这可能表明长链PUFAs在过敏发生中的致病作用。
Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development.