Nagelamides X-Z, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
Nagelamides X-Z, Dimeric Bromopyrrole Alkaloids from a Marine Sponge Agelas sp.
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DOI：
10.1021/ol401291n
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发表时间：
2013-07-05
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, Jun'ichi
中科院分区：
文献类型：
--
作者：
Tanaka, Naonobu;Kusama, Taishi;Kobayashi, Jun'ichi
从海绵Agelas sp.中分离得到三个新的二聚溴吡咯生物碱，命名为nagelamides X-Z（1-3），其中X（1）和Y（2）具有一个由四氢苯并氨基咪唑和氨基咪唑烷组成的新型三环骨架。Nagelamide Z（3）是第一个涉及C-8位二聚的二聚溴吡咯生物碱。化合物1-3的结构根据光谱数据进行了鉴定。Nagelamides X-Z（1-3）显示出抗微生物活性。
Three new dimeric bromopyrrole alkaloids, nagelamides X-Z (1-3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides X-Z (1-3) exhibited antimicrobial activity.