Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients
Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients
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DOI：
10.1016/j.cca.2009.07.020
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发表时间：
2009-10-01
影响因子：
5
通讯作者：
Huang, Mingfang
中科院分区：
文献类型：
--
作者：
Gai, Xiaobo;Lan, Xiaopeng;Huang, Mingfang
背景资料：MMP-9在致炎性心房重构的发病机制中起重要作用，并可能参与心房颤动（AF）的发生和持续。MMP-9基因的功能多态性，导致改变MMP-9的生产和/或活性可能会调节一个人的易感性AF。方法：共881例高血压心脏病患者的中国汉族人群（128与753无AF）在这项研究中招募。采用PCR-RFLP方法检测MMP-9 -1562C、T和R279 Q基因型。结果：AF组与对照组MMP-9基因-1562C>T多态性的基因型分布和等位基因频率差异均有统计学意义（P=0.007和P=0.002）。T等位基因携带者（TT + CT）与CC纯合子相比，AF的风险显著增加（OR 1.94。95%CI 1.20-3.14;校正P=0.006）。与CC纯合子相比，AF患者和对照组中T等位基因携带者血浆MMP-9水平也升高。结论：MMP-9基因-1562C>T多态性与中国汉族高血压性心脏病患者发生房颤的危险性显著相关。与MMP-9表达增加相关的-1562T等位基因可能是该队列中AF发生的遗传风险。(C)2009爱思唯尔有限公司版权所有。
Background: MMP-9 plays an important role in the pathogenesis of arrhythmogenic atrial remodeling, and may contribute to the development and persistence of atrial fibrillation (AF). Functional polymorphisms in the MMP-9 gene which lead to altered MMP-9 production and/or activity may modulate an individual's susceptibility to AF.Methods: A total of 881 hypertensive heart disease patients of Chinese Han population (128 with and 753 without AF) were recruited in this study. The MMP-9 -1562C>T and R279Q genotypes were determined using PCR-RFLP method. The plasma concentration of MMP-9 was measured by ELISA.Results: Both the genotype distributions and allele frequencies of the -1562C>T polymorphism were significantly different between the AF and control group (P=0.007 and P=0.002, respectively). The T allele carriers (TT + CT) had significantly increased risk of AF compared with the CC homozygotes (OR 1.94. 95% CI 1.20-3.14; adjusted P=0.006) in a logistic regression model after controlling age, left atrial dimension, and the use of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers. The T allele carriers also had increased plasma MMP-9 levels compared with CC homozygotes in both AF patients and control subjects. No relationship between R279Q polymorphism and AF was found in this cohort.Conclusions: The -1562C>T polymorphism of MMP-9 gene is significantly associated with AF risk in Chinese Han patients with hypertensive heart disease. The -1562T allele which is associated with increased expression of MMP-9 might be a genetic risk for the development of AF in this cohort. (C) 2009 Elsevier B.V. All rights reserved.