Glucose Homeostasis and Insulin Secretion During Chronic Treatment With Cyclosporin in Nondiabetic Humans
Glucose Homeostasis and Insulin Secretion During Chronic Treatment With Cyclosporin in Nondiabetic Humans
复制标题
非糖尿病人环孢素长期治疗期间的血糖稳态和胰岛素分泌
DOI：
10.2337/diab.38.1.s99
复制
发表时间：
1989
期刊：
影响因子：
7.7
通讯作者：
Lorene M. Nelson
中科院分区：
文献类型：
--
作者：
R. Robertson;Gary Franklin;Lorene M. Nelson
Cyclosporin or placebo was administered in a randomized, double-blind fashion to 13 patients with multiple sclerosis for 1 yr to determine whether cyclosporin adversely affects glucose homeostasis or β-cell function. No significant differences were observed in fasting glucose, fasting insulin, intravenous glucose tolerance, or glucose-induced insulin secretion before treatment or at 3 wk, 6 mo, or 1 yr during treatment. Longer therapeutic trials with larger patient groups will be necessary to decide whether cyclosporin can be safely given for many years without risk of developing diabetes mellitus.
