A GENETIC-POLYMORPHISM IN THE RENIN GENE OF DAHL RATS COSEGREGATES WITH BLOOD-PRESSURE
A GENETIC-POLYMORPHISM IN THE RENIN GENE OF DAHL RATS COSEGREGATES WITH BLOOD-PRESSURE
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DOI：
10.1126/science.2563177
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发表时间：
1989-01-27
期刊：
影响因子：
56.9
通讯作者：
DENE, H
中科院分区：
文献类型：
--
作者：
RAPP, JP;WANG, SM;DENE, H
血压受多个基因位点的影响，这些基因位点的身份在很大程度上是未知的。在Dahl盐高血压敏感（S）和Dahl盐高血压抵抗（R）大鼠之间发现了肾素基因的限制性片段长度多态性（RFLP）。在来自交叉S和R大鼠的F2群体中，肾素RFLP与血压共分离。一个剂量的S-大鼠肾素等位基因与血压升高约10 mmHg相关，两个剂量的该等位基因使血压升高约20 mmHg。由此可以明确地得出结论，在大鼠中，肾素基因是调节血压的基因之一，或者与调节血压的基因密切相关。
Blood pressure is influenced by multiple genetic loci whose identities are largely unknown. A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension-sensitive (S) and Dahl salt-hypertension-resistant (R) rats. In an F2 population derived from crossing S and R rats, the renin RFLP cosegregated with blood pressure. One dose of the S-rat renin allele was associated with an increment in blood pressure of approximately 10 mmHg, and two doses of this allele increased blood pressure approximately 20 mmHg. From this it can be definitively concluded that in the rat the renin gene is, or is closely linked to, one of the genes regulating blood pressure.