Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver
Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver
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DOI：
10.1038/sj.ijo.0802141
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发表时间：
2002-11-01
影响因子：
4.9
通讯作者：
Tokimitsu, I
中科院分区：
文献类型：
--
作者：
Murase, T;Nagasawa, A;Tokimitsu, I
目的：近年来，肥胖以惊人的速度增长，现已成为一个全球性的健康问题。我们研究了长期喂食茶儿茶素对C57BL/6J小鼠肥胖发展的影响。茶儿茶素是亚洲国家广泛食用的天然多酚化合物。设计：我们用低脂（5%甘油三酯（TG））、高脂（30% TG）或高脂添加0.1 - 0.5% （w/w）茶儿茶素的饲料喂养小鼠11个月，测量小鼠的体重、脂肪组织质量和肝脏脂肪含量。饲养1个月后测定β -氧化活性及相关mRNA水平。结果：补充茶儿茶素可以显著减少高脂肪饮食引起的体重增加、内脏和肝脏脂肪积累，以及高胰岛素血症和高瘦素血症的发生。饲喂1个月的茶儿茶素显著提高了肝脏酰基辅酶a氧化酶和中链酰基辅酶a脱氢酶mRNA表达和β -氧化活性。结论：刺激肝脏脂质代谢可能是茶儿茶素抗肥胖作用的重要机制之一。目前的研究结果表明，长期饮用茶儿茶素有利于抑制饮食性肥胖，并可能降低糖尿病和冠心病等相关疾病的风险。
OBJECTIVE: Obesity has increased at an alarming rate in recent years and is now a worldwide health problem. We investigated the effects of long-term feeding with tea catechins, which are naturally occurring polyphenolic compounds widely consumed in Asian countries, on the development of obesity in C57BL/6J mice.DESIGN: We measured body weight, adipose tissue mass and liver fat content in mice fed diets containing either low-fat (5% triglyceride (TG)), high-fat (30% TG), or high-fat supplemented with 0.1 - 0.5% (w/w) tea catechins for 11 months. The beta-oxidation activities and related mRNA levels were measured after 1 month of feeding.RESULTS: Supplementation with tea catechins resulted in a significant reduction of high-fat diet-induced body weight gain, visceral and liver fat accumulation, and the development of hyperinsulinemia and hyperleptinemia. Feeding with tea catechins for 1 month significantly increased acyl-CoA oxidase and medium chain acyl-CoA dehydrogenase mRNA expression as well as beta-oxidation activity in the liver.CONCLUSION: The stimulation of hepatic lipid metabolism might be a factor responsible for the anti-obesity effects of tea catechins. The present results suggest that long-term consumption of tea catechins is beneficial for the suppression of diet-induced obesity, and it may reduce the risk of associated diseases including diabetes and coronary heart disease.