Monitoring tobacco-specific N-nitrosamines and nicotine in novel smokeless tobacco products: findings from round II of the new product watch.
Monitoring tobacco-specific N-nitrosamines and nicotine in novel smokeless tobacco products: findings from round II of the new product watch.
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监测新型无烟烟草产品中烟草特有的 N-亚硝胺和尼古丁：新产品观察第二轮的调查结果。
DOI：
10.1093/ntr/ntu026
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Hatsukami,DorothyK
中科院分区：
文献类型：
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作者：
Stepanov,Irina;Biener,Lois;Yershova,Katrina;Nyman,AmyL;Bliss,Robin;Parascandola,Mark;Hatsukami,DorothyK
对新产品观察（NPW）第一轮（国家烟草监测网络）中购买的新型无烟烟草制品的分析表明，某些烟草成分不仅在不同品牌之间存在差异，而且在同一产品中存在区域和时间差异。在这项研究中，我们分析了在第二轮国家烟草计划中购买的鼻烟和可溶性烟草制品。方法分析2011年春夏在全国不同地区采购的鼻烟和可溶烟草制品中烟草特异性n -亚硝胺（TSNA）和尼古丁含量。结果与美国不同地区和不同产品的第一轮数据进行了比较。结果共收到来自全国6个地区不同州的216份样本。与以往的分析相比，万宝路、骆驼鼻烟和部分骆驼溶性产品的TSNA含量显著升高。本研究中万宝路鼻烟和骆驼鼻烟的未化尼古丁含量与第一轮无显著差异，但各地区差异显著；其中，万宝路鼻烟与骆驼鼻烟的最高、最低区域平均水平差异为3.2倍，骆驼鼻烟为1.7倍。结论一些新型无烟烟草制品的TSNA含量与传统湿鼻烟相当。对第一轮和第二轮NPW中未化尼古丁含量地区差异的观察表明，制造商可能会根据不同地区一致地调整这一成分的水平。
IntroductionAnalysis of novel smokeless tobacco products purchased in Round I of the New Product Watch (NPW)—a national tobacco monitoring network—demonstrated that some tobacco constituents vary not only across various brands but also regionally and over time within the same product. In this study, we analyzed snus and dissolvable tobacco products that were purchased in Round II of the NPW.MethodsWe analyzed tobacco-specificN-nitrosamines (TSNA) and nicotine in snus and dissolvable tobacco products that were purchased in various regions of the country during the spring and summer of 2011. The results were compared against the Round I data, across different U.S. regions, and among products.ResultsA total of 216 samples were received from different states representing 6 regions of the country. Compared with the previous analyses, TSNA levels increased significantly in Marlboro and Camel Snus and some dissolvable Camel products. The levels of unprotonated nicotine in Marlboro Snus and Camel Snus in this study were not different from Round I but varied significantly by regions; the differences between the highest and the lowest average regional levels were ~3.2-fold in Marlboro Snus ~1.7-fold in Camel Snus.ConclusionsOur results indicate that some novel smokeless tobacco products contain TSNA at the levels found in the conventional moist snuff. Observation of regional variations in unprotonated nicotine content in both Round I and Round II of NPW suggest that manufacturers may tailor the levels of this constituent consistently to different regions.