Selective total removal of a growth-hormone-secreting adenoma: evidence that acromegaly is a primary pituitary disease.
Selective total removal of a growth-hormone-secreting adenoma: evidence that acromegaly is a primary pituitary disease.
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选择性完全切除生长激素分泌腺瘤：肢端肥大症是原发性垂体疾病的证据。
DOI：
10.1016/0026-0495(79)90014-3
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
P. Jannetta
中科院分区：
文献类型：
--
作者：
Z. J. Wanski;A. G. Robinson;P. Jannetta
肢端肥大症是由脑垂体生长激素分泌过多引起的。关于该病的主要病因是垂体的异常下丘脑刺激还是原发性垂体瘤还存在一些争论。本文介绍了一个肢端肥大症的情况下，生长激素的动力学反应的刺激和抑制试验异常。经蝶窦腺瘤切除术后的小肿瘤，生长激素水平恢复正常，抑制和刺激试验结果恢复正常，术后1周内，并保持正常2年。研究结果表明，肢端肥大症在这种情况下是由于原发性垂体功能障碍。显微手术切除生长激素分泌肿瘤为研究肢端肥大症的病因提供了一个独特的机会。
Acromegaly is caused by hypersecretion of growth hormone by the pituitary. There is some debate as to whether the primary etiology of the disease is abnormal hypothalamic stimulation of the pituitary or a primary pituitary tumor. This paper presents a case of acromegaly in which growth hormone dynamics in response to stimulation and suppression tests were abnormal. After transsphenoidal adenomectomy of a small tumor, growth hormone levels returned to normal and suppression and stimulation test results reverted to normal within 1 wk postoperatively and remained normal for 2 yr. The findings suggest that the acromegaly in this case was due to a primary pituitary dysfunction. Microsurgical removal of growth-hormone-secreting tumors provides a unique opportunity to study the etiology of acromegaly.