Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.
Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.
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DOI：
10.1002/chem.201405275
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
A. Steib;O. Kuzmina;Sarah Fernandez;Sushant Malhotra;P. Knochel
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文献类型：
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作者：
A. Steib;O. Kuzmina;Sarah Fernandez;Sushant Malhotra;P. Knochel
氯化铬（II）催化二氯吡啶与一系列官能化（杂）芳族格氏试剂在室温下的化学选择性交叉偶联反应。官能团，如酯和缩醛，在这种转化中耐受良好。以前具有挑战性的底物，喹啉和异喹啉，参与在环戊基甲基醚（CPME）作为溶剂的选择性铬催化的交叉偶联。通过使用各种固体载体证明了Cr盐的有效清除。
Chromium(II) chloride catalyzes the chemoselective cross-coupling reaction of dichloropyridines with a range of functionalized (hetero)aromatic Grignard reagents at room temperature. Functional groups, such as esters and acetals, are well tolerated in this transformation. Previously challenging substrates, quinolines and isoquinolines, participate in the selective Cr-catalyzed cross-coupling in cyclopentyl methyl ether (CPME) as the solvent. The effective purging of Cr salts is demonstrated by using various solid supports.