TERT rs2736098 Polymorphism and Cancer Risk: Results of a Meta-analysis
TERT rs2736098 Polymorphism and Cancer Risk: Results of a Meta-analysis
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TERT rs2736098 多态性和癌症风险：荟萃分析结果
DOI：
10.7314/apjcp.2012.13.7.3483
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Gu, Ai-Hua
中科院分区：
文献类型：
--
作者：
Qi, Hao-Yu;Zou, Peng;Gu, Ai-Hua
Objective: Several studies have demonstrated associations between the TERT rs2736098 single nucleotide polymorphisms (SNPs) and susceptibility to cancer development. However, there are conflicting results. A systematic meta-analysis was therefore performed to establish the cancer risk associated with the polymorphism. Methods: In this meta-analysis, a total of 6 case-control studies, including 5,567 cases and 6,191 controls, were included. Crude odds ratios with 95% confidence intervals were used to assess the strength of associations in several genetic models. Results: Our results showed no association reaching the level of statistical significance for overall risk. Interestingly, in the stratified analyses (subdivided by ethnicity), significantly increased risks were found in the Asian subgroup which indicates the TERT rs2736098 polymorphism may have controversial involvement in cancer susceptibility. Conclusions: Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.
