Aging-Related Structural and Functional Changes in Cerebral Arteries: Caloric Restriction (CR) Intervention.
Aging-Related Structural and Functional Changes in Cerebral Arteries: Caloric Restriction (CR) Intervention.
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发表时间：
2021
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通讯作者：
Cipolla MJ
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作者：
Mandalà M;Cipolla MJ
脑动脉在调节流向大脑的血液以满足器官正常功能对氧气和葡萄糖的需求方面起着至关重要的作用。生理性脑血流量（CBF）响应于血压的变化而维持在正常范围内，这一机制称为脑血流量自动调节（CBFAR）。脑动脉的结构和功能对CBFAR有重要影响。对人类和动物的几项研究表明，老年脑的脑血管发生了显著的形态和功能变化，这与CBF减少有关，CBF也在与脑疾病相关的脑血管病理学中受损。有趣的是，一个新的新兴方面是终身热量限制（CR）作为一种潜在的干预措施，以防止与年龄相关的脑动脉变化和保护衰老大脑的健康。本文综述了近年来关于衰老对脑动脉结构和功能的影响以及CR作为预防和治疗机会的潜力的文献。
Cerebral arteries play a crucial role in the regulation of blood flow to the brain to satisfy the demand of oxygen and glucose for proper function of the organ. Physiological cerebral blood flow (CBF) is maintained within a normal range in response to changes in blood pressure a mechanism named Cerebral Blood Flow Auto Regulation (CBFAR). Structure and function of cerebral arteries have an important impact on CBFAR. Several studies in human and animals have showed significant morphological and functional changes in cerebral vessels of aged brain associated with a reduced CBF which is also impaired in cerebrovascular pathology linked to brain diseases. Interestingly, one new emergent aspect is the lifelong Calorie Restriction (CR) as a potential intervention to prevent age-related cerebral artery changes and preserve the health of aging brain. This review summarizes the recent literature on the effects of aging on cerebral artery structure and function and the potential of CR as opportunities for prevention and treatment.