Moderator Effects in a Randomized Controlled Trial of Exercise Training in Lymphoma Patients
Moderator Effects in a Randomized Controlled Trial of Exercise Training in Lymphoma Patients
复制标题
DOI：
10.1158/1055-9965.epi-09-0504
复制
发表时间：
2009-10-01
影响因子：
3.8
通讯作者：
Reiman, Tony
中科院分区：
文献类型：
--
作者：
Courneya, Kerry S.;Sellar, Christopher M.;Reiman, Tony
背景资料：淋巴瘤患者的健康运动试验表明，有氧运动训练改善了淋巴瘤患者的重要健康结果。在这里，我们研究潜在的主持人的运动训练response.Methods：淋巴瘤患者分层的主要疾病类型和目前的治疗状态，并随机分配到日常护理（n = 62）或有氧运动训练（n = 60）12周。终点是生活质量、心血管健康和身体成分。调节组分配，年龄，性别，婚姻状况，疾病阶段，体重指数，和一般health.Results患者的偏好没有统计学中度运动训练对生活质量的影响（P = 0.36），但7.8点的相互作用效果有利于患者没有偏好的临床意义。婚姻状况（P = 0.083）、总体健康状况（P = 0.012）和身体质量指数（P = 0.010）调节了有氧运动训练对生活质量的影响，未婚患者与已婚患者相比，健康状况差/一般的患者与健康状况良好至极好的患者相比，体重正常/肥胖的患者与超重的患者相比，结果更好。疾病分期（P = 0.056）和总体健康状况（P = 0.012）调节了有氧运动训练对身体成分的影响，晚期疾病患者的结局优于早期疾病/无疾病患者，健康状况良好患者的结局优于非常好到极好的健康状况。没有变量可以调节干预对心血管健康的影响。研究结果没有解释的差异adherence.Conclusions：临床可用的变量预测的生活质量和身体成分的反应，淋巴瘤患者的有氧运动训练。如果重复，这些结果可能会为未来的随机试验和临床实践提供信息。（癌症流行病学生物标志物Prev 2009;18（10）：2600-7）
Background: The Healthy Exercise for Lymphoma Patients trial showed that aerobic exercise training improved important health outcomes in lymphoma patients. Here, we examine potential moderators of the exercise training response.Methods: Lymphoma patients were stratified by major disease type and current treatment status and randomly assigned to usual care (n = 62) or aerobic exercise training (n = 60) for 12 weeks. Endpoints were quality of life, cardiovascular fitness, and body composition. Moderators were patient preference for group assignment, age, sex, marital status, disease stage, body mass index, and general health.Results: Patient preference did not statistically moderate the effects of exercise training on quality of life (P for interaction = 0.36), but the interaction effect of 7.8 points favoring patients with no preference was clinically meaningful. Marital status (P for interaction = 0.083), general health (P for interaction = 0.012), and body mass index (P for interaction = 0.010) moderated the effects of aerobic exercise training on quality of life with better outcomes for unmarried versus married patients, patients in poor/fair health versus good-to-excellent health, and normal weight/obese versus overweight patients. Disease stage (P for interaction = 0.056) and general health (P for interaction = 0.012) moderated the effects of aerobic exercise training on body composition with better outcomes for patients with advanced disease versus early disease/no disease and patients in good health versus very good-to-excellent health. No variables moderated intervention effects on cardiovascular fitness. Findings were not explained by differences in adherence.Conclusions: Clinically available variables predicted quality of life and body composition responses to aerobic exercise training in lymphoma patients. If replicated, these results may inform future randomized trials and clinical practice. (Cancer Epidemiol Biomarkers Prev 2009;18(10):2600-7)