A Novel Mechanism for Cyclic Adenosine Monophosphate-Mediated Memory Formation: Role of Amyloid Beta
A Novel Mechanism for Cyclic Adenosine Monophosphate-Mediated Memory Formation: Role of Amyloid Beta
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DOI：
10.1002/ana.24130
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发表时间：
2014-04-01
影响因子：
11.2
通讯作者：
Fedele, Ernesto
中科院分区：
文献类型：
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作者：
Ricciarelli, Roberta;Puzzo, Daniela;Fedele, Ernesto
环磷酸腺苷(CAMP)调节长时程增强(LTP)，改善健康和疾病大脑的记忆。越来越多的证据表明，在生理条件下，低浓度的淀粉样蛋白(A)是LTP表达和记忆形成所必需的。在这里，我们报道了cAMP控制淀粉样前体蛋白(APP)的翻译和A水平，并且cAMP对LTP的调节作用是通过刺激APP合成和A产生来实现的。Ann Neurol 2014；75：602-607
Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid (A) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and A levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and A production. Ann Neurol 2014;75:602-607