HIGH-DOSE NALOXONE AFFECTS TASK-PERFORMANCE IN NORMAL SUBJECTS
HIGH-DOSE NALOXONE AFFECTS TASK-PERFORMANCE IN NORMAL SUBJECTS
复制标题
DOI：
10.1016/0165-1781(83)90100-2
复制
发表时间：
1983-01-01
影响因子：
11.3
通讯作者：
MURPHY, DL
中科院分区：
文献类型：
--
作者：
COHEN, RM;COHEN, MR;MURPHY, DL
Increasing i.v. doses of naloxone (0.3, 1 and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented vs. nonpresented words of a single category (effortful processing) and the monitoring of the frequency of such presentations (automatic processing). At the same time working memory was left unaffected. A role for the opioid system in some memory processes in man is suggested.
