Galectin genes: Regulation of expression
Galectin genes: Regulation of expression
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DOI：
10.1023/b:glyc.0000014073.23096.3a
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Bruni, CB
中科院分区：
文献类型：
--
作者：
Chiariotti, L;Salvatore, P;Bruni, CB
本文综述了哺乳动物半乳糖凝集素表达的最新研究进展。可以进行的一个有趣的观察是，在近年来进行的大多数微阵列和/或差异显示分析中，已经拾取了一种或多种半乳糖凝集素。从相关研究的批判性评价中，可以得出的主要结论是，尽管目前尚不清楚迄今为止鉴定的14种半乳糖凝集素是否具有共同的功能，但所有半乳糖凝集素的一个显著共同特征是在发育、分化阶段和不同生理或病理条件下对其表达的强烈调节。这表明不同半乳糖凝集素的表达是微调的，并且可能是协调的。尽管有这些观察结果，但令人相当意外的是，对控制半乳糖凝集素基因活性的分子机制进行的研究很少。
In this review we have summarized the more recent studies on the expression of mammalian galectins. One interesting observation that can be made is that in most of microarrays and/or differential display analysis performed in recent years one or more galectins have been picked up. From a critical evaluation of the pertinent studies the main conclusion that can be drawn is that, although it is not yet clear whether the 14 galectins identified so far have functions in common, a striking common feature of all galectins is the strong modulation of their expression during development, differentiation stages and under different physiological or pathological conditions. This suggests that the expression of different galectins is finely tuned and possibly coordinated. In spite of these observations it is rather unexpected that very few studies have been performed on the molecular mechanisms governing the activity of galectin genes.