Hemodynamics in Coronary Arterial Tree of Serial Stenoses.
Hemodynamics in Coronary Arterial Tree of Serial Stenoses.
复制标题
连续狭窄冠状动脉树的血流动力学。
DOI：
10.1371/journal.pone.0163715
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Huo Y
中科院分区：
文献类型：
--
作者：
Chen X;Gao Y;Lu B;Jia X;Zhong L;Kassab GS;Tan W;Huo Y
连续节段性狭窄经常发生在人类，这会改变冠状动脉血流动力学，并进一步影响动脉粥样硬化的进展和斑块形成。本研究的目的是了解心外膜左冠状动脉主干（LMCA）树中血流动力学参数的分布，并根据患者计算机断层扫描血管造影（CTA）图像重建连续狭窄。结合进口压力波和出口流动阻力，采用有限体积法。从流场中确定了时均壁面剪切应力（TAWSS）和振荡剪切指数（OSI）。母血管狭窄主要影响分叉附近的血流动力学，而子血管狭窄则影响远端下游分叉。与单一狭窄相比，连续狭窄使沿心外膜左前降支动脉树主干的峰值压力梯度沿着增加> 50%。连续狭窄之间的距离增加进一步增加了峰值压差。这些发现对冠状动脉连续狭窄的诊断和治疗具有重要意义。
Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses.
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影响因子：
37.8
作者：
SEILER, C;KIRKEEIDE, RL;GOULD, L
通讯作者：
GOULD, L
DOI：
10.1016/0735-1097(93)90770-2
发表时间：
1993-12-01
影响因子：
24
作者：
PORTER, TR;SEARS, T;SHURMUR, S
通讯作者：
SHURMUR, S
影响因子：
37.8
作者：
Chatzizisis, Yiannis S.;Jonas, Michael;Stone, Peter H.
通讯作者：
Stone, Peter H.
影响因子：
24
作者：
Pijls, Nico H. J.;Fearon, William F.;De Bruyne, Bernard
通讯作者：
De Bruyne, Bernard
影响因子：
158.5
作者：
Stone, Gregg W.;Lansky, Alexandra J.;Mehran, Roxana
通讯作者：
Mehran, Roxana