Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3
Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3
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Cryptotanshinone 通过抑制 STAT3 的激活来减少银屑病表皮增生。
DOI：
10.1111/exd.13511
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发表时间：
2018-03-01
影响因子：
3.6
通讯作者：
Zheng, Guangjuan
中科院分区：
文献类型：
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作者：
Tang, Lipeng;He, Songmin;Zheng, Guangjuan
寻找能够有效、安全地预防表皮增生的新治疗药物对于银屑病来说迫在眉睫。 Cryptotanshinone (CTS) 是从丹参根中分离出来的活性成分，据报道具有抗菌和抗肿瘤作用。然而，其对牛皮癣的作用尚未见报道。在这里，我们研究了 CTS 对咪喹莫特 (IMQ) 诱导的银屑病样皮肤模型的治疗作用，并探讨了其潜在机制。我们的结果表明，CTS 有效缓解 IMQ 诱导的表皮增生。体外研究还表明，CTS 有效抑制角质形成细胞的生长。我们进一步发现细胞生长的转录因子STAT3是CTS对角质形成细胞增殖的关键介质。综上所述，我们的研究结果表明CTS对银屑病的疗效主要是通过调节STAT3来实现的，这为开发CTS作为银屑病患者的潜在治疗剂提供了证据。
The discovery of new therapeutic drugs with the efficacious and safe ability to prevent epidermal hyperplasia is extremely urgent for psoriasis. Cryptotanshinone (CTS), an active component isolated from the root of Salvia miltiorrhiza Bunge, has been reported to have antibacterial and antitumor effects. However, its effects on psoriasis have not been reported. Here, we investigated the therapeutic effects of CTS on imiquimod (IMQ)-induced psoriatic-like skin model and explored the underlying mechanisms. Our results revealed that CTS effectively alleviates IMQ-induced epidermal hyperplasia. In vitro studies also indicated that CTS potently inhibits the growth of keratinocytes. We further found that STAT3, a transcription factor for the cell growth, is the key mediator of CTS on the proliferation of keratinocytes. Taken together, our findings indicated that the curative effects of CTS on psoriasis are accomplished mainly through modulating STAT3, which providing evidences to develop CTS as a potential therapeutic agent for patients with psoriasis.