Essential role for Max in early embryonic growth and development.
Essential role for Max in early embryonic growth and development.
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DOI：
10.1101/gad.14.1.17
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发表时间：
2000-01
影响因子：
10.5
通讯作者：
Shen-Li Hong;R. O'Hagan;Harry Hou;James W. Horner;H. Lee;H. Lee;Ronald A. DePinho
中科院分区：
文献类型：
--
作者：
Shen-Li Hong;R. O'Hagan;Harry Hou;James W. Horner;H. Lee;H. Lee;Ronald A. DePinho
小鼠Max功能丧失导致植入后早期（约E5.5-6.5）胚胎和胚外组织的全面发育停滞，与体内扩张胚胎和体外胚泡生长中母体Max储备的丧失或稀释一致。发育停滞的胚胎体积缩小，表现出广泛的细胞学变性和微弱的BrdU掺入。Max和Myc超家族在早期哺乳动物发育中发挥重要作用，并且Max的母体储存库存在足够的量以维持Myc超家族在发育的植入前阶段的功能。
Loss of Max function in the mouse resulted in generalized developmental arrest of both embryonic and extraembryonic tissues at early postimplantation (approximately E5.5-6.5), coincident with loss or dilution of maternal Max stores in the expanding embryo in vivo and in blastocyst outgrowths in vitro. Developmentally arrested embryos were reduced in size and exhibited widespread cytological degeneration and feeble BrdU incorporation. Max and, by extension, the Myc superfamily, serve essential roles in early mammalian development and a maternal reservoir of Max exists in sufficient amount to sustain Myc superfamily function through preimplantation stages of development.