Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency.
Chronic venous abnormalities in symptomatic and asymptomatic protein C deficiency.
复制标题
有症状和无症状蛋白 C 缺乏症导致的慢性静脉异常。
DOI：
10.1111/j.1538-7836.2005.01452.x
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Bovill,EG
中科院分区：
文献类型：
--
作者：
Emmerich,J;Vossen,CY;Callas,PW;Demers,C;Naud,S;Long,GL;Couture,P;Rosendaal,FR;Bovill,EG
BackgroundThrombophilia is a frequent medical condition associated with symptomatic deep vein thrombosis (DVT). Unlike other clinical risk factors associated with DVT, such as surgery, thrombophilia has not been demonstrated to be associated with asymptomatic venous thrombotic events. Our aim was to search for asymptomatic sequelae of DVT in a protein C (PC)‐deficient family.MethodsWe studied 228 individuals from a large kindred with PC deficiency and performed a systematic ultrasound examination.ResultsAmong the 203 patients without a known history of venous thrombosis we found seven patients with abnormalities indicative of prior asymptomatic thrombosis: six (7.4%) in the PC‐deficient group (n= 81) and only one (0.8%) in the non‐deficient group (n= 122). The relative risk for these sequelae associated with PC deficiency was 9.0 (95% CI: 1.1–73.7).ConclusionsThese data suggest that chronic venous abnormalities are frequently present and that thrombotic events in asymptomatic individuals with familial PC deficiency may be underestimated.
