Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers.
Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers.
复制标题
ADRB2和ADRB1中的遗传多态性与接受β受体阻滞剂的心力衰竭患者的差异生存有关。
DOI：
10.1038/s41397-021-00257-1
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Duarte JD
中科院分区：
文献类型：
--
作者：
Guerra LA;Lteif C;Arwood MJ;McDonough CW;Dumeny L;Desai AA;Cavallari LH;Duarte JD
Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if SNPs previously associated with BB response are also associated with differential survival in heart failure (HF) patients receiving BBs. HF patient data were derived from electronic health records and the Social Security Death Index. Associations and interactions between BB dose, SNP genotype, and the outcome of death were assessed using a Cox proportional hazard model adjusting for covariates known to be associated with differential survival in HF patients. Two SNPs, ADRB1 Arg389Gly and ADRB2 Glu27Gln, displayed significant interactions (Pint = 0.043 and Pint = 0.017, respectively) with BB dose and their association with mortality. Our study suggests that ADRB2 27Glu and ADRB1 389Arg may confer a larger survival benefit with higher BB doses in patients with HF.
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影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
37.8
作者：
Heckbert, SR;Hindorff, LA;Tracy, RP
通讯作者：
Tracy, RP
影响因子：
5.9
作者：
Forleo, C;Resta, N;Pitzalis, MV
通讯作者：
Pitzalis, MV
影响因子：
2
作者：
HESS, KR
通讯作者：
HESS, KR
影响因子：
18.2
作者：
Fiuzat, Mona;Neely, Megan L.;O'Connor, Christopher M.
通讯作者：
O'Connor, Christopher M.