Correlates and Causes of Death in Patients With Severe Symptomatic Aortic Stenosis Who Are Not Eligible to Participate in a Clinical Trial of Transcatheter Aortic Valve Implantation
Correlates and Causes of Death in Patients With Severe Symptomatic Aortic Stenosis Who Are Not Eligible to Participate in a Clinical Trial of Transcatheter Aortic Valve Implantation
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DOI：
10.1161/circulationaha.109.926873
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发表时间：
2010-09-14
期刊：
影响因子：
37.8
通讯作者：
Waksman, Ron
中科院分区：
文献类型：
--
作者：
Ben-Dor, Itsik;Pichard, Augusto D.;Waksman, Ron
背景-目前正在评估经导管主动脉瓣植入术在被认为是高风险手术候选人的严重主动脉瓣狭窄患者中的应用。本研究的目的是检测发病率，原因，和相关的死亡率在患者不符合条件，参与经导管主动脉瓣植入study.Methods和Results-From 2007年4月至2009年7月，一个队列的362例严重主动脉瓣狭窄进行了筛选，并没有满足必要的纳入/排除标准，参与经导管主动脉瓣植入试验。这些患者分为2组：第1组（内科）：274例（75.7%）：97例（35.4%）接受内科治疗，177例（64.6%）接受球囊主动脉瓣成形术治疗;第2组（外科）：88例（24.3%）。与外科手术组相比，药物/球囊主动脉瓣成形术组的临床风险显著更高，胸外科医师协会评分显著更高（12.8 +/- 7.0 vs 8.5 +/- 5.1; P
Background-Transcatheter aortic valve implantation is currently being evaluated in patients with severe aortic stenosis who are considered high-risk surgical candidates. This study aimed to detect incidences, causes, and correlates of mortality in patients ineligible to participate in transcatheter aortic valve implantation studies.Methods and Results-From April 2007 to July 2009, a cohort of 362 patients with severe aortic stenosis were screened and did not meet the inclusion/exclusion criteria necessary to participate in a transcatheter aortic valve implantation trial. These patients were classified into 2 groups: group 1 (medical): 274 (75.7%): 97 (35.4%) treated medically and 177 (64.6%) treated with balloon aortic valvuloplasty; and group 2 (surgical): 88 (24.3%). The medical/balloon aortic valvuloplasty group had significantly higher clinical risk compared with the surgical group, with significantly higher Society of Thoracic Surgeons score (12.8 +/- 7.0 versus 8.5 +/- 5.1; P