Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages.
Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages.
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胸腺细胞选择相关HMG盒因子(TOX)是CD4T细胞、自然杀伤T细胞和T调节细胞发育所必需的DNA结合因子。在此，我们发现在没有TOX的情况下，NK细胞发育和淋巴组织器官生成都受到抑制。我们发现，淋巴组织诱导细胞的发育需要TOX，这是一种罕见的特化细胞亚群，在淋巴组织器官发生中起着不可或缺的作用。TOX在骨髓中未成熟的NK细胞中高度上调，这与缺乏这种核蛋白时成熟的NK细胞的丧失是一致的。因此，免疫系统中的多个细胞谱系共享TOX依赖的发育步骤。
Thymocyte selection-associated HMG box factor (TOX) is a DNA-binding factor required for development of CD4 T cells, natural killer T cells, and T regulatory cells. Here we document that both NK cell development and lymphoid tissue organogenesis are inhibited in the absence of TOX. We find that development of lymphoid tissue inducer cells, a rare subset of specialized cells that plays an integral role in lymphoid tissue organogenesis, requires TOX. Tox is highly upregulated in immature NK cells in the bone marrow, consistent with the loss of mature NK cells in the absence of this nuclear protein. Thus, multiple cell lineages in the immune system share a TOX-dependent step for development.