Application of PNA and LNA oligomers to chemotherapy.
Application of PNA and LNA oligomers to chemotherapy.
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发表时间：
2001-04
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通讯作者：
A. Elayadi;D. Corey
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作者：
A. Elayadi;D. Corey
肽核酸（PNA）和锁定核酸（LNA）寡聚物以极高的亲和力与互补序列结合。这种高亲和力结合支持了它们在靶向细胞核酸方面具有优势的假设，并为基于寡核苷酸的抗增殖药物的开发提供了更好的途径。本文综述了PNA和LNA低聚物的性质，并描述了它们在癌症治疗中的应用所面临的挑战。
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.