Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2
Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2
复制标题
DOI：
10.1006/geno.1998.5565
复制
发表时间：
1998-12-01
期刊：
影响因子：
4.4
通讯作者：
Gallatin, WM
中科院分区：
文献类型：
--
作者：
Kilgannon, P;Turner, T;Gallatin, WM
细胞间粘附分子5（ICAM-5，telencephalin）是在哺乳动物脑的最吻段（端脑）中的神经元上表达的细胞粘附分子。在啮齿动物和兔子中的抗体研究已经证明了这种分子在这些神经元的细胞体和树突上的表达。我们研究了表达模式。用北方印迹法对16个人脑节段进行分析。该分析证实了该ICAM在人体中的独特表达模式。此外，我们报告了人类ICAM-5基因定位到染色体19p13.2上的一个80 kb区域，该区域也包含ICAM-1和ICAM-3。(C)北京：科学出版社.
Intercellular adhesion molecule 5 (ICAM-5, telencephalin) is a cell adhesion molecule expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Antibody studies in rodents and rabbits have demonstrated expression of this molecule on the cell body and dendrites of these neurons. We have examined the expression pattern. in human brain by Northern blot analysis of 16 human brain segments. This analysis has confirmed the unique expression pattern of this ICAM in human. In addition, we report the mapping of the human ICAM-5 gene to an 80-kb region on chromosome 19p13.2 that also contains ICAM-1 and ICAM-3. (C) 1998 Academic Press.