miR-210: fine-tuning the hypoxic response.
miR-210: fine-tuning the hypoxic response.
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DOI：
10.1007/978-1-4614-5915-6_10
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发表时间：
2014
影响因子：
--
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Ivan M;Huang X
缺氧是肿瘤微环境的核心组成部分，也是癌症治疗失败的主要原因。最近的工作提供了大量证据，表明非编码 RNA，特别是 microRNA，是肿瘤对低氧适应性反应的重要成员。所有已发表的研究都一致认为，miR-210 是缺氧诱导因子的有力靶标，并且 miR-210 的诱导是正常细胞和转化细胞缺氧反应的一致特征。大多数实体瘤中均检测到 miR-210 的过度表达，并且与软组织肉瘤、乳腺癌、头颈癌和胰腺癌患者的不良预后相关。多种 miR-210 靶标已被鉴定，指出其在细胞周期、线粒体氧化代谢、血管生成、DNA 损伤反应和细胞存活中的作用。额外的 microRNA 似乎以一种更具组织特异性的方式受到低氧的调节，为大量受缺氧调节的蛋白质编码基因增加了另一层复杂性。
Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members of the adaptive response to low oxygen in tumors. All published studies agree that miR-210 specifically is a robust target of hypoxia-inducible factors, and the induction of miR-210 is a consistent characteristic of the hypoxic response in normal and transformed cells. Overexpression of miR-210 is detected in most solid tumors and has been linked to adverse prognosis in patients with soft-tissue sarcoma, breast, head and neck, and pancreatic cancer. A wide variety of miR-210 targets have been identified, pointing to roles in the cell cycle, mitochondrial oxidative metabolism, angiogenesis, DNA damage response, and cell survival. Additional microRNAs seem to be modulated by low oxygen in a more tissue-specific fashion, adding another layer of complexity to the vast array of protein-coding genes regulated by hypoxia.