Nanocellulose in biomedicine: Current status and future prospect
Nanocellulose in biomedicine: Current status and future prospect
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DOI：
10.1016/j.eurpolymj.2014.07.025
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发表时间：
2014-10-01
影响因子：
6
通讯作者：
Dufresne, Alain
中科院分区：
文献类型：
--
作者：
Lin, Ning;Dufresne, Alain
纳米纤维素是从天然纤维素中提取的一种独特的、有前途的天然材料，由于其优异的物理性能、特殊的表面化学性质和优良的生物学特性（生物相容性、生物降解性和低毒性），作为生物医用材料受到了广泛关注。本文介绍了纤维素纳米晶体（CNC）、纤维素纳米纤丝（CNF）和细菌纤维素（BC）三种不同类型的纳米纤维素，并从生产、性质和生物医学应用方面进行了比较。通过对纳米纤维素基生物医用材料的最新研究成果（特别是近5年来的报道）的分析，对纳米纤维素基生物医用材料的研究进展进行了综述和讨论。本文重点介绍了近年来在纳米纤维素生物医学领域取得的一些重要研究成果，并从分子水平对纳米纤维素在生物医学领域的应用进行了探讨（例如，用于细胞培养的组织生物支架;药物赋形剂和药物递送;以及酶/蛋白质的固定和识别）以及宏观生物材料水平（例如血管和软组织替代物;皮肤和骨组织修复材料;以及抗菌材料）。纳米纤维素的功能化修饰将决定其潜在的生物医学应用，这也是本文的一个单独部分。最后，在第五节中提出了未来的展望和可能的研究重点。(C)2014由Elsevier Ltd.出版
Nanocellulose, a unique and promising natural material extracted from native cellulose, has gained much attention for its use as biomedical material, because of its remarkable physical properties, special surface chemistry and excellent biological properties (biocompatibility, biodegradability and low toxicity). Three different types of nanocellulose, viz. cellulose nanocrystals (CNC), cellulose nanofibrils (CNF) and bacterial cellulose (BC), are introduced and compared in terms of production, properties and biomedical applications in this article. The advancement of nanocellulose-based biomedical materials is summarized and discussed on the analysis of latest studies (especially reports from the past five years). Selected studies with significant findings are emphasized, and focused topics for nanocellulose in biomedicine research in this article include the discussion at the level of molecule (e.g. tissue bioscaffolds for cellular culture; drug excipient and drug delivery; and immobilization and recognition of enzyme/protein) as well as at the level of macroscopic biomaterials (e.g. blood vessel and soft tissue substitutes; skin and bone tissue repair materials; and antimicrobial materials). Functional modification of nanocellulose will determine the potential biomedical application for nanocellulose, which is also introduced as a separated section in the article. Finally, future perspectives and possible research points are proposed in Section 5. (C) 2014 Published by Elsevier Ltd.