Clinical prognostic factors in canine histiocytic sarcoma
Clinical prognostic factors in canine histiocytic sarcoma
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DOI：
10.1111/vco.12252
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发表时间：
2017-12-01
影响因子：
2.1
通讯作者：
Cesario, L.
中科院分区：
文献类型：
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作者：
Dervisis, N. G.;Kiupel, M.;Cesario, L.
犬组织细胞肉瘤（HS）是一种侵袭性肿瘤，具有不同的临床病程和致死性结局。本研究的目的是评估一个大型队列的犬患者与病理化学证实的HS和确定临床预后因素。向密歇根州立大学提交的具有暂定HS诊断的活检报告经组织学和化学方法确认，收集医疗记录，并与相关兽医诊所进行面谈。在1391份组织病理学报告中，诊断包含“组织细胞”一词，335份疑似恶性肿瘤，180份与HS一致，并记录了足够的临床信息。最常见的品种是伯尔尼山地犬（n = 53），拉布拉多猎犬（n = 26）和金毛猎犬（n = 17）。研究中所有犬的中位生存期为170天，亚组分析确定姑息治疗、播散性HS和同时使用皮质类固醇是单变量和多变量方法中统计学显著的生存负面因素。
Canine histiocytic sarcoma (HS) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort of canine patients with immunohistochemically confirmed HS and identify clinical prognostic factors. Biopsy submissions to the Michigan State University with tentative HS diagnoses were histologically and immunohistochemically confirmed, medical records collected, and interviews with relevant veterinary clinics conducted. Of 1391 histopathology submissions with a diagnosis containing the word histiocytic', 335 were suspicious for malignancy, and 180 were consistent with HS and had adequate clinical information recorded. The most commonly represented breeds were Bernese mountain dogs (n = 53), labrador retrievers (n = 26) and golden retrievers (n = 17). Median survival for all dogs in the study was 170 days, and subgroup analysis identified palliative treatment, disseminated HS, and concurrent use of corticosteroids as statistically significant negative factors for survival, in both uni- and multi-variate methodologies.