KineticDB: a database of protein folding kinetics.

KineticDB: a database of protein folding kinetics.
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KineticDB:蛋白质折叠动力学数据库。

DOI:
10.1093/nar/gkn696
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Ivankov, Dmitry N.
Ivankov, Dmitry N.
中科院分区:
生物学2区
文献类型:
--
作者:
Bogatyreva, Natalya S.;Osypov, Alexander A.;Ivankov, Dmitry N.

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我们在这里提出KineticDB,一个系统编译的蛋白质折叠动力学数据库,其中包含约90个独特的蛋白质。KineticDB的主要目标是为用户提供实验确定的各种蛋白质折叠速率。对蛋白质折叠决定因素的研究仍在进行中,旨在获得对折叠过程的新理解。在过去的10年里,与实验蛋白质折叠速率的比较一直是验证理论模型和经验关系的主要工具。因此,有必要以简单易用的方式为研究人员提供尽可能多的数据。目前,KineticDB包含单结构域蛋白质和分离蛋白质结构域以及没有二硫键的短肽的折叠动力学测量结果。它包括在过去10年中系统积累的大约90种独特蛋白质和许多突变体的数据,是作为数据库提供的最大的蛋白质折叠动力学数据集。KineticDB可在http://kineticdb.protres.ru/db/index.pl上获得。
We propose here KineticDB, a systematically compiled database of protein folding kinetics, which contains about 90 unique proteins. The main goal of the KineticDB is to provide users with a diverse set of protein folding rates determined experimentally. The search for determinants of protein folding is still in progress, aimed at obtaining a new understanding of the folding process. Comparison with experimental protein folding rates has been the main tool for validation of both theoretical models and empirical relationships during the last 10 years. It is, therefore, necessary to provide a researcher with as much data as possible in a simple and easy-to-use way. At present, the KineticDB contains the results of folding kinetics measurements of single-domain proteins and separate protein domains as well as short peptides without disulfide bonds. It includes data on about 90 unique proteins and many mutants that have been systematically accumulated over the last 10 years and is the largest collection of protein folding kinetic data presented as a database. The KineticDB is available at http://kineticdb.protres.ru/db/index.pl.
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