PirB functions as an intrinsic suppressor in hippocampal neural stem cells.
PirB functions as an intrinsic suppressor in hippocampal neural stem cells.
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PirB 作为海马神经干细胞的内在抑制因子
DOI：
10.18632/aging.203134
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发表时间：
2021-06-13
期刊：
影响因子：
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通讯作者：
Yang C
中科院分区：
文献类型：
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作者：
Liu B;Cheng W;Cheng D;Pu J;Nie Z;Xia C;Chen Y;Yang C
神经干细胞在产前发育和整个生命过程中发挥着关键作用。在这里，我们报告成对免疫球蛋白样受体B（Pir B）的功能作为一个抑制剂在脑神经发生在成年小鼠。PirB的表达在发育过程中随着年龄的增长而增加，其缺陷促进了体内和体外神经干细胞的增殖和分化。此外，我们检测到PirB缺陷小鼠中的1型神经干细胞与其野生型同窝仔相比有所增加。PirB缺乏通过激活Akt1磷酸化促进Sox 2和KLF 4的干标记基因表达。这些发现表明PirB抑制神经干细胞的自我更新和分化能力。因此，PirB可能具有作为治疗靶点的潜力，用于治疗由于衰老或其他病理状况而导致的成人神经发生减少。
Neural stem cells play pivotal roles during prenatal development and throughout life. Here, we report that Paired immunoglobulin-like receptor B (PirB) functions as a suppressor during brain neurogenesis in the adult mouse. PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation and differentiation in vivo and in vitro. Furthermore, we detected an increase in Type 1 neural stem cells in PirB-deficient mice compared to their wild-type littermates. PirB deficiency promoted stemness marker gene expression of Sox2 and KLF4 by activating Akt1 phosphorylation. These findings suggest that PirB inhibits the self-renewal and differentiation capacities of neural stem cells. Thus, PirB may have the potential to serve as a therapeutic target for treatment of reduced neurogenesis in adults due to aging or other pathological conditions.