Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay.
Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay.
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DOI：
10.1002/hbm.23023
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发表时间：
2016-01
影响因子：
4.8
通讯作者：
Suckling J
中科院分区：
文献类型：
--
作者：
Floris DL;Lai MC;Auer T;Lombardo MV;Ecker C;Chakrabarti B;Wheelwright SJ;Bullmore ET;Murphy DG;Baron-Cohen S;Suckling J
在人类中，语言和精细运动技能都与左脑专门化有关，而视觉空间技能与右半球专门化有关。患有自闭症谱系障碍(ASC)的人表现出一系列缺陷和优势，涉及到这些偏侧的认知功能。在这里，我们测试了这样的假设，即在ASC患者中，这些功能所涉及的区域非典型地向右偏侧，并且这种非典型与功能表现有关。参与者包括67名患有ASC的右利手男性成年人和69名年龄和智商匹配的神经典型男性。我们通过基于体素的灰质体积分析来评估感兴趣皮质区域结构不对称性的组间差异，然后通过语言、运动和视觉空间技能的测量进行相关分析。我们发现在顶叶下小叶有更强的向右偏侧化，而向左偏侧化沿着包括颞叶平面、Heschl‘s回、后缘上回和顶盖的听觉皮质延伸，这在有语言延迟的ASC患者中比无语言发作的患者更明显。有计划的相关分析表明，对于ASC患者来说，听力区域向左不对称的减少与童年时期更多的社会互惠困难有关。我们得出结论，非典型脑结构不对称是ASC潜在的候选神经表型。Hum Brain Mapp 37：230-253,2016。©2015作者人脑图谱由Wiley期刊出版公司出版。
In humans, both language and fine motor skills are associated with left‐hemisphere specialization, whereas visuospatial skills are associated with right‐hemisphere specialization. Individuals with autism spectrum conditions (ASC) show a profile of deficits and strengths that involves these lateralized cognitive functions. Here we test the hypothesis that regions implicated in these functions are atypically rightward lateralized in individuals with ASC and, that such atypicality is associated with functional performance. Participants included 67 male, right‐handed adults with ASC and 69 age‐ and IQ‐matched neurotypical males. We assessed group differences in structural asymmetries in cortical regions of interest with voxel‐based analysis of grey matter volumes, followed by correlational analyses with measures of language, motor and visuospatial skills. We found stronger rightward lateralization within the inferior parietal lobule and reduced leftward lateralization extending along the auditory cortex comprising the planum temporale, Heschl's gyrus, posterior supramarginal gyrus, and parietal operculum, which was more pronounced in ASC individuals with delayed language onset compared to those without. Planned correlational analyses showed that for individuals with ASC, reduced leftward asymmetry in the auditory region was associated with more childhood social reciprocity difficulties. We conclude that atypical cerebral structural asymmetry is a potential candidate neurophenotype of ASC. Hum Brain Mapp 37:230–253, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.